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Updated: May 3, 2026

Measuring Lactase Enzymatic Activity in the Teaching Lab
Published on: August 6, 2018
Lactose intolerance: from diagnosis to correct management.
T Di Rienzo1, G D'Angelo, F D'Aversa
1Department of Internal Medicine and Gastroenterology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy. veronica.ojetti@tin.it.
Lactose intolerance affects 75% of the global population, causing digestive issues. Management involves dietary changes and medication, with diagnosis often via a lactose hydrogen breath test.
Area of Science:
- Gastroenterology
- Human Physiology
- Nutritional Science
Background:
- Lactose intolerance is a prevalent gastrointestinal issue.
- Most individuals lose the ability to digest lactose after infancy.
- Lactose is the primary carbohydrate in milk.
Purpose of the Study:
- To review the role of lactase-persistence alleles.
- To discuss the diagnosis of lactose malabsorption.
- To explore the development and management of lactose intolerance symptoms.
Main Methods:
- Literature review of lactose intolerance.
- Discussion of diagnostic methods like the lactose hydrogen breath test.
- Analysis of management strategies including dietary restriction and drug therapy.
Main Results:
- Approximately 75% of the world's population experiences lactose malabsorption.
- Symptoms vary significantly among individuals and include bloating, diarrhea, and abdominal pain.
- Effective management strategies are available.
Conclusions:
- Lactose intolerance is a common condition with diverse symptoms.
- Diagnosis is typically achieved through non-invasive breath testing.
- Management options include dietary modification and pharmacological interventions.
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