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Processing, signaling, and physiological function of chemerin.

Andreas Mattern1, Tristan Zellmann, Annette G Beck-Sickinger

  • 1Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Universität Leipzig, Leipzig, Germany.

IUBMB Life
|January 22, 2014
PubMed
Summary
This summary is machine-generated.

Chemerin is an immunomodulating protein involved in inflammation. This review summarizes its processing, signaling via CMKLR1 and CCRL2 receptors, and its role in skin health and diseases like psoriasis.

Keywords:
CMKLR1chemerininflammationobesitypsoriasisskin

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Area of Science:

  • Immunology
  • Dermatology
  • Biochemistry

Background:

  • Chemerin is an immunomodulating factor secreted by adipose tissue and skin.
  • It activates the G-protein coupled receptor chemokine-like receptor 1 (CMKLR1), influencing immune cell migration.
  • The non-signaling receptor C-C chemokine receptor-like 2 (CCRL2) also plays a role in inflammation.

Purpose of the Study:

  • To summarize current understanding of chemerin processing and signaling.
  • To focus on the regulation of chemerin activity and its receptors.
  • To discuss the controversial role of chemerin in diseases, including skin conditions.

Main Methods:

  • Literature review and synthesis of existing research on chemerin.
  • Analysis of studies on chemerin processing by proteases.
  • Examination of research on chemerin receptor interactions (CMKLR1 and CCRL2).

Main Results:

  • Chemerin processing is linked to inflammatory proteases.
  • Chemerin signaling through CMKLR1 induces chemotaxis of immune cells.
  • CCRL2's role in inflammation and chemerin's function in healthy and diseased skin are highlighted.

Conclusions:

  • Chemerin is a key player in immune responses, particularly in the skin.
  • Understanding chemerin's complex signaling and receptor interactions is crucial.
  • Further research is needed to clarify its precise role in various inflammatory diseases.