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Related Concept Videos

Esophageal Achalasia01:27

Esophageal Achalasia

45
Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide...
45

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Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
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Automated impedance manometry analysis as a method to assess esophageal function.

N Rommel1, L Van Oudenhove, J Tack

  • 1Translational Research Center for Gastrointestinal Diseases (TARGID), KU Leuven, Leuven, Belgium; Neurogastroenterology and Motility, Gastroenterology, University Hospital Leuven, Leuven, Belgium; Neurosciences, ExpORL, KU Leuven, Leuven, Belgium.

Neurogastroenterology and Motility
|January 23, 2014
PubMed
Summary

Automated impedance manometry (AIM) analysis reveals new esophageal pressure-flow variables that accurately differentiate between healthy individuals and those with dysphagia based on bolus consistency. This method improves diagnosis by correlating objective measures with patient-reported symptoms.

Keywords:
Esophageal motilitydysphagiahigh resolution manometryimpedance measurement

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Area of Science:

  • Gastroenterology
  • Esophageal Physiology
  • Diagnostic Imaging

Background:

  • Evaluating esophageal dysphagia is challenging due to unclear links between symptoms, esophageal contractions, and bolus flow.
  • Automated impedance manometry (AIM) is a novel approach to analyze pressure-impedance data.

Purpose of the Study:

  • To evaluate AIM analysis in relation to bolus characteristics, Chicago classification metrics, bolus perception, and dysphagia.
  • To identify novel esophageal pressure-flow variables for diagnosing dysphagia.

Main Methods:

  • AIM analysis was applied to high-resolution manometry-impedance recordings from 12 healthy controls and 15 dysphagia patients.
  • Analysis included 10 liquid, 10 semisolid, and 10 solid swallows per subject using AIMplot software.

Main Results:

  • Esophageal pressure-flow parameters varied significantly with bolus type (liquid, semisolid, solid).
  • Impedance at peak pressure accurately discriminated normal from dysphagic subjects (AUC > 0.83).
  • Nadir impedance and impedance at peak pressure strongly correlated with perceived esophageal bolus flow.

Conclusions:

  • Novel esophageal pressure-flow variables were identified in healthy subjects and dysphagia patients.
  • These variables are altered by bolus consistency and can distinguish dysphagia patients from controls.
  • AIM analysis provides high-resolution esophageal pressure-flow variables that link to patient perception of bolus hold-up.