Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

119
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
119
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

782
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
782
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.4K
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

873
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
873
Microbiome of the Eye01:22

Microbiome of the Eye

67
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
67
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

2.4K
Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyperspectral imaging reveals early drought stress and associated molecular responses in lettuce for space agriculture.

Plant phenomics (Washington, D.C.)·2026
Same author

Patterns of postoperative opioid dispensing among Medicaid beneficiaries, 2016-2017 and 2021-2022.

The journal of pain·2026
Same author

Explainable deep learning framework for fecal contamination detection on chicken eggshells via portable fluorescence imaging under ambient light.

Poultry science·2026
Same author

Uganda Public Health Fellowship Program's Contributions to Malaria Control Programs 2015-2022: Strategies, Implementation Challenges, and Opportunities.

Global health, science and practice·2026
Same author

AutoPET Challenge on Fully Automated Lesion Segmentation in Oncologic PET/CT Imaging, Part 2: Domain Generalization.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Assessment of High-Volume Antibiotic and Opioid Prescribing by Medicare Part D Prescribers-United States, 2021.

Public health reports (Washington, D.C. : 1974)·2025

Related Experiment Video

Updated: May 3, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

11.8K

Fungal endophthalmitis associated with compounded products.

Christina A Mikosz, Rachel M Smith, Moon Kim

    Emerging Infectious Diseases
    |January 23, 2014
    PubMed
    Summary

    Outbreaks of fungal endophthalmitis occurred after eye procedures due to contaminated compounded medications. These infections, linked to Brilliant Blue G dye and triamcinolone acetonide, led to widespread vision loss and product recalls.

    Keywords:
    Bipolaris hawaiiensisFranck’sFusarium incarnatum-equiseticompoundingdisease outbreaksendophthalmitiseye infectionsfungalfungimold

    More Related Videos

    Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
    10:33

    Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

    Published on: December 17, 2021

    4.3K
    Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
    06:19

    Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

    Published on: May 31, 2024

    1.9K

    Related Experiment Videos

    Last Updated: May 3, 2026

    Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
    07:24

    Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

    Published on: February 6, 2021

    11.8K
    Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
    10:33

    Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

    Published on: December 17, 2021

    4.3K
    Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
    06:19

    Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

    Published on: May 31, 2024

    1.9K

    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Public Health

    Background:

    • Fungal endophthalmitis is a severe ocular infection.
    • In March 2012, a national outbreak of fungal endophthalmitis was identified following invasive ocular procedures.

    Purpose of the Study:

    • To investigate the cause of concurrent fungal endophthalmitis outbreaks.
    • To identify the source and associated risk factors for these infections.

    Main Methods:

    • Retrospective case-control study involving 47 patients across 9 states.
    • Microbiological analysis of patient specimens and compounded drug products.
    • Epidemiological investigation to determine exposure and risk factors.

    Main Results:

    • Two distinct outbreaks were identified, linked to a single compounding pharmacy.
    • One outbreak involved Brilliant Blue G (BBG) dye (Fusarium incarnatum-equiseti complex), the other triamcinolone acetonide (Bipolaris hawaiiensis).
    • Exposure to either compounded product was the sole identified risk factor; 98% of affected patients experienced vision loss.

    Conclusions:

    • Contaminated compounded medications pose a significant risk for serious ocular infections.
    • Ensuring the safety and integrity of compounded pharmaceuticals is crucial for preventing patient harm.
    • These outbreaks necessitated product recalls and highlighted the need for stringent regulatory oversight.