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Updated: May 3, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Cassane-type diterpenoids from the seed kernels of Caesalpinia bonduc
Lin Wu1, Jun Luo1, Yangmei Zhang1
1State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Abstract:
Seven new cassane diterpenoids (1-7), along with three known compounds (8-10), were isolated from the seed kernels of Caesalpinia bonduc. The structures were elucidated by extensive 1D and 2D NMR (HSQC, HMBC and ROESY) and mass (HRESIMS) spectroscopic data analyses. The structure and absolute configuration of compound 1 were confirmed by a single-crystal X-ray diffraction experiment. All isolates were tested for their cytotoxicity against HepG-2, MCF-7 and MG-63 cells, and 8-10 showed weak inhibitory activities.
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