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Trace-forward investigation of mice in response to lymphocytic choriomeningitis virus outbreak
Abstract:
During follow-up of a 2012 US outbreak of lymphocytic choriomeningitis virus (LCMV), we conducted a trace-forward investigation. LCMV-infected feeder mice originating from a US rodent breeding facility had been distributed to >500 locations in 21 states. All mice from the facility were euthanized, and no additional persons tested positive for LCMV infection.
Insights
A 2012 US outbreak investigation traced lymphocytic choriomeningitis virus (LCMV) to infected mice. The trace-forward found no additional human infections after all mice from the facility were euthanized.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Public Health
Background:
- A 2012 outbreak of lymphocytic choriomeningitis virus (LCMV) in the US prompted further investigation.
- LCMV is a potentially serious viral disease transmitted by rodents.
Purpose of the Study:
- To conduct a trace-forward investigation following the 2012 LCMV outbreak.
- To identify the source and extent of LCMV transmission from infected rodents.
Main Methods:
- Trace-forward investigation methodology was employed.
- Tracking of LCMV-infected feeder mice originating from a US rodent breeding facility.
- Monitoring of distribution to over 500 locations across 21 states.
Main Results:
- LCMV-infected mice were distributed to more than 500 locations in 21 states.
- All mice from the identified breeding facility were euthanized.
- No additional human cases of LCMV infection were detected following the intervention.
Conclusions:
- The trace-forward investigation successfully identified the source of LCMV spread.
- Euthanasia of infected rodents effectively halted further transmission.
- Public health measures were successful in preventing additional human infections.
