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Drug delivery system design and development for boron neutron capture therapy on cancer treatment
Lin-Chiang Sherlock Huang1, Wen-Yuan Hsieh2, Jiun-Yu Chen3
1Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC; Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC.
Abstract:
We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.
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