Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

41
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
41
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

56
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
56
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.8K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.8K
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

13.6K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
13.6K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

6.4K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.4K
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

35
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
35

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD90 mediates gastric cancer immune evasion though regulating IGF2BP2 to stabilize the m6A-CD47/SIRPα axis.

Cancer cell international·2026
Same author

Associations of Family Physical Activity Support and 24-Hour Movement Behaviors with Physical Fitness in Preschool Children: A Focus on MVPA.

Healthcare (Basel, Switzerland)·2026
Same author

Guardians of immunity: the role of tumour-draining lymph node in cancer immunity.

Frontiers in cell and developmental biology·2026
Same author

Generation of aptamers for the selective detection and neutralization of soluble lymphotoxin alpha.

Molecular therapy. Nucleic acids·2026
Same author

Unveiling the nature of ligand-modulated argentophilic interactions: a theoretical study of intra- and intermolecular silver complexes.

Physical chemistry chemical physics : PCCP·2026
Same author

MMP28 promotes tumorigenesis and gemcitabine resistance in pancreatic cancer by promoting glycolysis through interaction with SND1.

Biochemical pharmacology·2025
Same journal

Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression.

Angiogenesis·2026
Same journal

Endothelial protein C receptor and the endothelial progenitor paradigm: towards a functional definition at last.

Angiogenesis·2026
Same journal

Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer.

Angiogenesis·2026
Same journal

A possible microvascular vulnerability in carotid artery dissection: insights from nailfold capillaroscopy.

Angiogenesis·2026
Same journal

miR-150 controls developmental angiogenesis via ribosome biogenesis-dependent regulation of Notch signaling.

Angiogenesis·2026
Same journal

MCC links Wnt/PCP signaling to endothelial polarity and vascular remodeling.

Angiogenesis·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

13.8K

Inflammation-induced lymphangiogenesis and lymphatic dysfunction.

Shan Liao1, Pierre-Yves von der Weid

  • 1Inflammation Research Network, Snyder Institute for Chronic Diseases, Calgary, AB, T2N 4N1, Canada.

Angiogenesis
|January 23, 2014
PubMed
Summary
This summary is machine-generated.

The lymphatic system is crucial for fluid balance and immune response. This review details how inflammation and cancer alter lymphatic functions, impacting disease progression.

More Related Videos

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

6.5K
Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
08:07

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

10.6K

Related Experiment Videos

Last Updated: May 3, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

13.8K
Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

6.5K
Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
08:07

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

10.6K

Area of Science:

  • Immunology
  • Physiology
  • Pathology

Background:

  • The lymphatic system maintains tissue fluid balance and facilitates immune cell movement.
  • These lymphatic functions are essential for initiating and developing inflammatory responses.
  • Recent research shows significant lymphatic system alterations during inflammation and disease.

Purpose of the Study:

  • To review the lymphatic system's role in chronic inflammation and cancer.
  • To examine how diseases modify lymphatic functions.
  • To assess the impact of these lymphatic changes on disease progression.

Main Methods:

  • Literature review of recent findings on lymphatic system function in disease.
  • Analysis of changes in lymphangiogenesis and lymphatic contractility.
  • Examination of the interplay between lymphatic dysfunction and disease pathogenesis.

Main Results:

  • Inflammation and cancer induce significant changes in both vascular and nodal lymphatic systems.
  • Lymphatic contractile dysfunction and lymphangiogenesis are common in disease states.
  • Altered lymphatic function influences the spread and severity of inflammatory conditions and cancer.

Conclusions:

  • The lymphatic system plays a critical role in the pathogenesis of chronic inflammation and cancer.
  • Understanding lymphatic system alterations is key to developing new therapeutic strategies.
  • Targeting lymphatic dysfunction may offer novel approaches for disease management.