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Related Experiment Videos

Delayed tissue necrosis due to mitomycin C.

H Aizawa1, H Tagami

  • 1Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.

Acta Dermato-Venereologica
|January 1, 1987
PubMed
Summary
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A patient developed a severe ulcer from mitomycin C extravasation three months after injection, triggered by alcohol consumption. This rare delayed-onset ulcer highlights the importance of monitoring extravasation sites.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Mitomycin C is an antineoplastic agent used in cancer treatment.
  • Extravasation, or leakage of infused medication into surrounding tissues, can cause local injury.
  • Delayed complications from mitomycin C extravasation are infrequently reported.

Observation:

  • A patient received intravenous mitomycin C without immediate signs of tissue damage.
  • Three months post-infusion, the patient consumed alcohol.
  • A severe ulcer subsequently developed at the prior mitomycin C extravasation site.

Findings:

  • The patient experienced a delayed-onset ulceration at the mitomycin C extravasation site.
  • Alcohol consumption appeared to be a trigger for the ulcer formation.

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  • This case represents a rare instance of a long-latency ulcer following mitomycin C extravasation.

    • Implications:

    • This case underscores the potential for delayed tissue injury from mitomycin C extravasation.
    • Physicians should be aware of the possibility of late-developing complications, even without initial signs of damage.
    • Further investigation into the mechanisms of delayed ulcer formation after mitomycin C extravasation is warranted.