Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

860
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
860
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

Imaging Studies V: Intravenous Urography and Retrograde Pyelography

3.5K
IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rethinking Perioperative Strategies in Clinically Node-positive Upper Tract Urothelial Carcinoma in the KEYNOTE-B15 Era.

European urology·2026
Same author

Additivity, Not Synergy, Underlies the Efficacy of Current Combination Regimens in Urothelial Cancer.

Cancer research communications·2026
Same author

Sasanlimab taken together with Bacillus Calmette-Guérin (BCG) compared with BCG alone in people with high-risk non-muscle invasive bladder cancer: a plain language summary.

Future oncology (London, England)·2026
Same author

TROPION-Urothelial03: a phase II/III study of datopotamab deruxtecan (Dato-DXd) for locally advanced or metastatic urothelial carcinoma.

Future oncology (London, England)·2026
Same author

Gemcitabine plus nivolumab with carboplatin or oxaliplatin in cisplatin-ineligible patients with metastatic urothelial carcinoma: a randomized phase II trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

How enfortumab vedotin plus pembrolizumab affects the quality of life of people with advanced urothelial cancer compared with platinum-based chemotherapy: a plain language summary of patient-reported outcomes from the EV-302 study.

Future oncology (London, England)·2026

Related Experiment Video

Updated: May 3, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

9.5K

New developments in urothelial cancer.

Matthew D Galsky1

  • 1From the Tisch Cancer Institute, Division of Hematology and Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, NY.

American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting
|January 24, 2014
PubMed
Summary

Urothelial cancer shows sensitivity to chemotherapy, but advanced cases have short response durations. Future treatments may involve biomarkers and targeted therapies for better outcomes in advanced urothelial cancer.

More Related Videos

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

7.1K
Integration of Electroporation in Urological Practice: Design and Evaluation of a New Transurethral Electrode
04:34

Integration of Electroporation in Urological Practice: Design and Evaluation of a New Transurethral Electrode

Published on: March 20, 2026

171

Related Experiment Videos

Last Updated: May 3, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

9.5K
Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

7.1K
Integration of Electroporation in Urological Practice: Design and Evaluation of a New Transurethral Electrode
04:34

Integration of Electroporation in Urological Practice: Design and Evaluation of a New Transurethral Electrode

Published on: March 20, 2026

171

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Urothelial cancer is highly sensitive to chemotherapy.
  • Advanced urothelial cancer patients experience short response durations with conventional treatments.
  • Second-line therapies offer limited efficacy and poor outcomes.

Purpose of the Study:

  • To explore novel therapeutic strategies beyond conventional cytotoxic drugs for advanced urothelial cancer.
  • To identify promising areas for optimizing patient selection and treatment efficacy.

Main Methods:

  • Review of current treatment limitations for advanced urothelial cancer.
  • Identification of emerging research directions, including biomarker integration and targeted therapies.

Main Results:

  • Conventional cytotoxic drugs have reached an efficacy ceiling in unselected patient populations.
  • Predictive biomarkers, oncogenomic mutation targeting, and combination therapies show promise.

Conclusions:

  • Optimizing patient selection through biomarkers is crucial for improving urothelial cancer treatment.
  • Targeting oncogenic pathways and combining tumor- with immune-targeting strategies are key areas for future research.
  • Expanding evidence generation beyond narrow clinical trial criteria is needed to benefit the general urothelial cancer patient population.