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Updated: Aug 10, 2026

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
Published on: February 23, 2024
Acute aphasia and loss of vision with desferrioxamine overdose
1Division of Pediatric Hematology-Oncology, University Children's Hospital, Bonn, F.R.G.
Abstract:
Reversible aphasia, loss of vision, bradycardia, and mild hypotension occurred in a 6-year-old girl with aplastic anemia and transfusion-related iron overload after inadvertent increase of her intravenous desferrioxamine drip. Signs and symptoms were reversed promptly by intravenous fluids, suggesting that desferrioxamine, when given as a sudden intravenous bolus, may upset vasoregulation. Three possible mechanisms are discussed that could explain this phenomenon. High-dose intravenous desferrioxamine ought to be given by pump infusion only, in order to avoid accidental overdose.
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