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Updated: May 3, 2026
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Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
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Clinical implications of pathogenic calcium crystals
Frédéric Lioté1, Hang-Korng Ea
1aSorbonne Paris Cité, University Paris Diderot bInserm, UMR S606/1332, Centre Viggo Petersen, Hôpital Lariboisière cAP-HP, Hôpital Lariboisière, Pôle Appareil Locomoteur, Service de Rhumatologie A, Centre Viggo Petersen, Paris, France.
Current Opinion in Rheumatology
|January 24, 2014
Summary
Intraarticular calcifications, including calcium pyrophosphate and basic calcium phosphate crystals, directly contribute to cartilage destruction in osteoarthritis through crystal-induced stress and synovitis.
Area of Science:
- Rheumatology
- Orthopedics
- Crystal-induced arthropathies
Background:
- Intraarticular calcifications have been historically debated regarding their role in cartilage destruction.
- Osteoarthritis (OA) pathogenesis involves complex mechanisms, including potential contributions from calcifications.
Purpose of the Study:
- To review the prevalence and mechanisms of articular cartilage calcifications.
- To elucidate the pathogenic role of calcium pyrophosphate (CPP) and basic calcium phosphate (BCP) crystals in OA.
Main Methods:
- Literature review focusing on prevalence, mechanisms, and pathogenicity of articular cartilage calcifications.
- Synthesis of evidence regarding CPP and BCP crystal involvement in cartilage damage.
Main Results:
- Articular cartilage calcifications are prevalent and arise through various mechanisms.
- Both CPP and BCP crystals demonstrate a direct pathogenic role in cartilage destruction.
Conclusions:
- Calcium crystals induce cartilage stress and trigger acute or chronic synovitis, contributing to OA progression.
- Understanding crystal pathogenicity is crucial for managing osteoarthritis and related joint diseases.
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