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Live-cell Imaging of Lysosomal Membrane Permeabilization During Necroptosis
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Live-cell Imaging of Lysosomal Membrane Permeabilization During Necroptosis

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Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Tom Vanden Berghe1, Andreas Linkermann2, Sandrine Jouan-Lanhouet3

  • 11] Molecular Signaling and Cell Death Unit, Inflammation Research Center, Flanders Institute for Biotechnology (VIB), Ghent University, 9052 Ghent, Belgium. [2].

Nature Reviews. Molecular Cell Biology
|January 24, 2014
PubMed

Insights

Regulated necrosis, including necroptosis, involves genetically controlled cell death. Understanding diverse pathways like parthanatos and ferroptosis offers therapeutic targeting opportunities.

Area of Science:

  • Molecular biology
  • Cellular biology
  • Biochemistry

Background:

  • Cell death research has evolved with the discovery of regulated necrosis.
  • Necroptosis, mediated by RIPK1 and RIPK3-MLKL, is a well-characterized form of regulated necrosis.
  • Emerging research identifies other regulated necrosis pathways, including parthanatos, oxytosis, ferroptosis, NETosis, pyronecrosis, and pyroptosis.

Purpose of the Study:

  • To review the molecular mechanisms of various regulated necrosis pathways.
  • To highlight the interconnectedness of these cell death pathways.
  • To explore the therapeutic potential of targeting regulated necrosis.

Main Methods:

  • Literature review of cell death research.
  • Analysis of molecular signaling in regulated necrosis.
  • Comparison of different regulated necrosis pathways.

Main Results:

  • Regulated necrosis encompasses multiple genetically controlled cell death mechanisms beyond necroptosis.
  • These pathways share molecular components and regulatory networks.
  • RIPK1 and RIPK3-MLKL are central to necroptosis, but other pathways involve distinct molecular players.

Conclusions:

  • Understanding the molecular interplay between diverse regulated necrosis pathways is crucial.
  • Targeting these interconnected pathways holds promise for novel therapeutic strategies in diseases involving cell death.

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