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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

A double-imprinted diffraction-grating sensor based on a virus-responsive super-aptamer hydrogel derived from an

Wei Bai¹, David A Spivak

¹Department of Chemistry, Louisiana State University, Baton Rouge, LA 70802 (USA).

Angewandte Chemie (International Ed. in English)

|January 24, 2014

Summary

A new virus detection method uses a novel hydrogel sensor that can be read by the naked eye. This Molecularly Imprinted Polymer Gel Laser Diffraction Sensor (MIP-GLaDiS) offers sensitive detection of the Apple Stem Pitting Virus (ASPV).

Keywords:

aptamers molecular imprinting molecular recognition responsive hydrogels viruses

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Last Updated: May 3, 2026

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Engineering Antiviral Agents via Surface Plasmon Resonance

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Published on: June 14, 2022

Sample Preparation for Single Virion Atomic Force Microscopy and Super-resolution Fluorescence Imaging

Sample Preparation for Single Virion Atomic Force Microscopy and Super-resolution Fluorescence Imaging

Published on: January 2, 2014

Area of Science:

Biotechnology
Materials Science
Sensor Technology

Background:

Virus detection is crucial across biomedicine, environmental science, and biosecurity.
Existing methods often require expensive equipment and trained personnel.
There is a need for accessible, low-cost virus detection systems.

Purpose of the Study:

To develop a novel, cost-effective virus detection method.
To create a sensor readable by the naked eye.
To achieve high sensitivity in virus detection.

Main Methods:

A "double imprinting" technique was employed to create virus-bioimprinted hydrogels.
Imprint-lithography was used to micromold hydrogels into diffraction grating sensors.
A Molecularly Imprinted Polymer Gel Laser Diffraction Sensor (MIP-GLaDiS) was fabricated.

Main Results:

The MIP-GLaDiS system successfully detected the Apple Stem Pitting Virus (ASPV).
The sensor achieved a low limit of detection (LOD) of 10 ng/mL.
The diffraction pattern could be visually assessed by the naked eye.

Conclusions:

The MIP-GLaDiS offers a promising, naked-eye readable platform for virus detection.
This method rivals the sensitivity of established techniques like ELISA.
The technology has potential for widespread application in various scientific fields.