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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Heart failure with preserved ejection fraction
Marzia Rigolli1, Gillian A Whalley2
1Awhina Health Campus, Waitakere Hospital, Waitemata District Health Board, Private Bag 93-503, Auckland, New Zealand ; Division of Cardiology, University of Verona, Ospedale Maggiore, Ple Stefani 1, 37126 Verona, Italy.
Journal of Geriatric Cardiology : JGC
|January 24, 2014
Summary
Heart failure with preserved ejection fraction (HF-PEF) affects many elderly individuals, presenting a significant health challenge. Current treatments lack evidence for improving outcomes in this complex condition.
Area of Science:
- Cardiology
- Geriatrics
- Public Health
Background:
- Rising life expectancy increases heart failure (HF) prevalence, particularly in the elderly.
- Heart failure with preserved ejection fraction (HF-PEF) accounts for nearly half of HF cases.
- HF-PEF is a complex syndrome with multiple contributing cardiovascular abnormalities.
Purpose of the Study:
- To review current knowledge on HF-PEF diagnosis, prognosis, and treatment.
- To highlight pathological characteristics of HF-PEF in the elderly population.
Main Methods:
- Literature review of recent studies on HF-PEF.
- Synthesis of information on diagnostic criteria and prognostic factors.
- Analysis of current treatment strategies and their limitations.
Main Results:
- HF-PEF is a complex condition with evolving understanding beyond diastolic dysfunction.
- No evidence-based treatments currently improve clinical outcomes for HF-PEF.
- The elderly population presents unique pathological considerations for HF-PEF.
Conclusions:
- HF-PEF remains a significant and challenging health problem.
- Effective, evidence-based treatments for HF-PEF are urgently needed.
- Further research into HF-PEF pathophysiology, especially in the elderly, is crucial.
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