Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

64.7K
Overview
64.7K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
Autoimmune Disorders01:29

Autoimmune Disorders

2.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K
What is the Immune System?01:38

What is the Immune System?

99.2K
Overview
99.2K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

14.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiplexed antigen panel analysis identifies B cell phenotype and receptor genetic contributions to antibody breadth.

Immunity·2026
Same author

Reinforcement learning for real-time adaptive radiotherapy.

Artificial intelligence in medicine·2026
Same author

Benchmarking overlapping community detection methods for applications in human connectomics.

Network neuroscience (Cambridge, Mass.)·2026
Same author

Quantification and comparison of anti-AAV9 and anti-AAVrh74 antibodies in plasma and human milk: Implications for AAV-based gene therapy candidacy.

Journal of neuromuscular diseases·2025
Same author

Disease diagnostics using machine learning of B cell and T cell receptor sequences.

Science (New York, N.Y.)·2025
Same author

A peptide mimic of SOCS1 modulates equine peripheral immune cells <i>in vitro</i> and ocular effector functions <i>in vivo</i>: implications for recurrent uveitis.

Frontiers in immunology·2025

Related Experiment Video

Updated: May 3, 2026

Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

33.7K

Th17 cells in immunity and autoimmunity.

Simone Kennedy Bedoya1, Brandon Lam1, Kenneth Lau1

  • 1Department of Microbiology and Cell Science, University of Florida, P.O. Box 110700, Museum Road Building 981, Gainesville, FL 32611, USA.

Clinical & Developmental Immunology
|January 24, 2014
PubMed
Summary

T helper 17 (Th17) cells and IL-17 are crucial for fighting infections but also implicated in autoimmune diseases. This review highlights new evidence suggesting Th17 cells may protect against type 1 diabetes (T1D) with gut microbiota.

More Related Videos

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

3.2K
Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

52.8K

Related Experiment Videos

Last Updated: May 3, 2026

Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

33.7K
Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

3.2K
Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

52.8K

Area of Science:

  • Immunology
  • Microbiome Research
  • Autoimmunity

Background:

  • T helper 17 (Th17) cells and their cytokine Interleukin-17 (IL-17) are essential for combating extracellular bacterial and fungal infections.
  • The Th17 lineage is strongly implicated in the pathogenesis of numerous autoimmune disorders, including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma.
  • The role of Th17 cells in type 1 diabetes (T1D) remains controversial, with debate surrounding their involvement in disease pathogenicity versus protection.

Purpose of the Study:

  • To provide a comprehensive overview of the pathogenicity and function of Th17 cells.
  • To present novel evidence regarding the protective role of Th17 cells in the context of T1D.
  • To explore the interplay between Th17 cells, gut microbiota, and T1D onset and progression.

Main Methods:

  • Literature review and synthesis of existing research on Th17 cells and IL-17.
  • Analysis of current evidence linking Th17 cells to autoimmune diseases.
  • Examination of emerging data on the protective functions of Th17 cells in T1D.

Main Results:

  • Th17 cells and IL-17 are critical for host defense against specific pathogens.
  • Dysregulation of Th17 cells is a common feature in various autoimmune conditions.
  • Emerging evidence suggests a potential protective role for Th17 cells in T1D, particularly in conjunction with gut microbiota.

Conclusions:

  • Th17 cells exhibit a dual role, contributing to autoimmunity while also potentially protecting against T1D.
  • The gut microbiota appears to modulate the function of Th17 cells, influencing T1D development.
  • Further research is warranted to fully elucidate the complex role of Th17 cells in T1D and harness this understanding for therapeutic strategies.