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A new dihydroagarofuranoid sesquiterpene from the roots of Tripterygium hypoglaucum
Zhen-Zhen Liu1, Rong-Hua Zhao, Yue-Tao Liu
1a Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College , Beijing , 100193 , China.
Abstract:
A new sesquiterpene ester (1) has been isolated from the root bark of Tripterygium hypoglaucum. The structure was determined as 1α-acetoxy-6β,9β-dibenzoyloxy-4β-hydroxy-dihydroagarofuran by the extensive analysis of NMR data, and the absolute configurations were established as 1R, 4R, 6S, and 9R by application of the CD excitation chirality method. Compound 1 exhibited weak cytotoxicity against HeLa cells, with an IC₅₀ value of 30.2 μM.
