Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brucellosis remains a neglected disease in the developing world: a call for interdisciplinary action.

BMC public health·2018
Same author

Identification of Brucella spp. in feral swine (Sus scrofa) at abattoirs in Texas, USA.

Zoonoses and public health·2017
Same author

A Case-control Study of Haemorrhagic Septicaemia in Buffaloes and Cattle in Karachi, Pakistan, in 2012.

Transboundary and emerging diseases·2015
Same author

A randomised phase IIb trial to assess the efficacy of ReCharge ice cream in preventing chemotherapy-induced diarrhoea.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2015
Same author

Demographics, management and survival of patients with malignant pleural mesothelioma in the National Lung Cancer Audit in England and Wales.

Lung cancer (Amsterdam, Netherlands)·2015
Same author

Considering endoscopic design: a snakebot prototype.

IEEE pulse·2014

Related Experiment Video

Updated: May 3, 2026

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
06:32

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

29.1K

Peripheral neuroblastomas in dogs: a case series.

A M Arenas-Gamboa1, M Tanabe2, J Edwards2

  • 1Department of Veterinary Pathobiology, Texas A&M University, College of Veterinary Medicine and Biomedical Sciences, College Station, TX, USA; Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M University, Health Science Center, College Station, TX, USA.

Journal of Comparative Pathology
|January 25, 2014
PubMed
Summary

Peripheral neuroblastic tumors (PNTs) in dogs are rare, with nine cases of canine peripheral neuroblastoma documented. These tumors, often found in young dogs, show a potential breed predisposition in Labrador retrievers and boxers.

Keywords:
Labrador retrieverdogneoplasiaperipheral neuroblastoma

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

3.1K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.7K

Related Experiment Videos

Last Updated: May 3, 2026

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
06:32

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

29.1K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

3.1K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.7K

Area of Science:

  • Veterinary Pathology
  • Canine Oncology
  • Neurobiology

Background:

  • Peripheral neuroblastic tumors (PNTs) encompass a spectrum of sympathetic nervous system progenitor cell differentiation.
  • Peripheral neuroblastoma is characterized by undifferentiated neuroblastic cells with limited neuronal differentiation.
  • Canine peripheral neuroblastoma is an infrequently reported condition.

Purpose of the Study:

  • To document and characterize nine cases of canine peripheral neuroblastoma.
  • To investigate the clinicopathological features and immunohistochemical profile of these tumors.
  • To explore potential breed predispositions for canine peripheral neuroblastoma.

Main Methods:

  • Retrospective case review of nine canine peripheral neuroblastomas.
  • Histopathological examination including assessment of cellular morphology and rosette formation.
  • Immunohistochemical analysis using markers such as S100, neuron-specific enolase, synaptophysin, chromogranin A, and tyrosine hydroxylase.

Main Results:

  • The majority of cases occurred as large masses in the craniodorsal abdominal cavity of young dogs (mean age 3 years).
  • Histopathology revealed round to oval cells with scant cytoplasm and hyperchromatic nuclei; Homer-Wright rosettes were present in three cases.
  • Immunohistochemistry confirmed a neurogenic origin, with neoplastic cells positive for neuroendocrine markers and negative for vimentin, cytokeratin, CD3, and CD79a.
  • A potential breed predisposition was suggested, with 44% of cases in Labrador retrievers and 22% in boxers.

Conclusions:

  • Canine peripheral neuroblastoma is a rare tumor typically affecting young dogs and often presenting as large abdominal masses.
  • Immunohistochemical findings support a neurogenic differentiation of these canine tumors.
  • The study suggests a possible breed predisposition, particularly in Labrador retrievers and boxers, warranting further investigation.