Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human interferons: structure and function.

K C Zoon1

  • 1Division of Virology, Food and Drug Administration, Bethesda, MD 20892.

Interferon
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Virology. Mutation rate and genotype variation of Ebola virus from Mali case sequences.

Science (New York, N.Y.)·2015
Same author

Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene.

Journal of virology·2010
Same author

Important drug warning: Immune Globulin Intravenous (human) (IGIV) products.

Neonatal network : NN·2002
Same author

Leukocyte reduction filters may cause hypotension.

Clinical journal of oncology nursing·2000
Same author

Hypotension and bedside leukocyte reduction filters.

International journal of trauma nursing·2000
Same author

Challenges for biological standardization and control in the 21st century.

Developments in biological standardization·2000
Same journal

Interferons alpha and beta as cellular regulatory molecules.

Interferon·1987
Same journal

Alpha interferons in hairy cell leukaemia: a clinical model of biological therapy for cancer.

Interferon·1987
Same journal

The interferon-interleukin 1 connection.

Interferon·1987
Same journal

Interferons and autoimmunity.

Interferon·1987
Same journal

Interferon and human immunodeficiency virus infection.

Interferon·1987
Same journal

Autocrine interferon and the suppression of the c-myc nuclear oncogene.

Interferon·1987
See all related articles

Research on Interferons (IFNs) is advancing with studies on fragments and hybrid molecules. Future crystal structures will reveal three-dimensional interactions with receptors, enhancing our understanding of IFN biological activities.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • Interferons (IFNs) are crucial proteins with diverse biological activities.
  • Previous research explored IFN fragments, hybrid molecules, and monoclonal antibodies.
  • Recent reviews have covered these aspects, highlighting ongoing interest.

Purpose of the Study:

  • To review current knowledge on Interferon (IFN) structure and function.
  • To emphasize the significance of upcoming crystal structure data for human IFNs.
  • To explore the potential for understanding IFN-receptor interactions in three dimensions.

Main Methods:

  • Analysis of recombinant DNA technology for IFN fragment and hybrid molecule preparation.
  • Utilization of monoclonal antibodies for IFN characterization.

Related Experiment Videos

  • Anticipation of crystallographic data for human IFN structures.

    • Main Results:

    • IFN fragments and hybrid molecules offer insights into structure-function relationships.
    • Monoclonal antibodies have significantly advanced understanding of IFN properties.
    • The forthcoming crystal structures are expected to be pivotal.

    Conclusions:

    • Understanding IFN structure and function is critical for their therapeutic applications.
    • Three-dimensional structural data will elucidate the mechanisms of IFN-receptor binding.
    • This knowledge will enable a deeper comprehension of IFN-mediated biological responses.