X-inactivation: Xist RNA uses chromosome contacts to coat the X
Karen N Leung1, Barbara Panning2
1Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA; Department of Anatomy, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA.
Abstract:
The mechanisms by which Xist RNA associates with the X chromosome to mediate alterations in chromatin structure remain mysterious. Recent genome-wide Xist RNA distribution studies suggest that this long noncoding RNA uses 3-dimensional chromosome contacts to move to its sites of action.
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