Hydration and urinary pseudoephedrine levels after a simulated team game
Daniel Jolley1, Brian Dawson, Shane K Maloney
1School of Sport Science, Exercise, and Health, University of Western Australia, Crawley, Western Australia.
International Journal of Sport Nutrition and Exercise Metabolism
|January 25, 2014
Summary
Dehydration does not affect urinary pseudoephedrine (PSE) levels in athletes during prolonged exercise. Urinary PSE concentrations varied unpredictably, with many exceeding the World Anti-Doping Agency (WADA) limit, advising athletes to avoid PSE during competition.
Area of Science:
- Sports Science
- Exercise Physiology
- Anti-Doping
Background:
- Pseudoephedrine (PSE) is a common medication.
- Athletes may use PSE for cold symptoms.
- Hydration status can influence drug excretion.
Purpose of the Study:
- To investigate the impact of dehydration on urinary pseudoephedrine (PSE) levels.
- To assess PSE excretion during prolonged exercise under different hydration conditions.
- To determine if hydration status affects PSE levels relative to the World Anti-Doping Agency (WADA) threshold.
Main Methods:
- Fourteen athletes underwent a simulated team game circuit (STGC) under hydrated, dehydrated, and post-exercise fluid bolus conditions.
- Pseudoephedrine (PSE) was administered before and during the STGC.
- Urinary PSE levels, body mass, and urine specific gravity were measured.
Main Results:
- No significant differences in urinary PSE levels were observed between hydration conditions.
- Urinary PSE concentrations exhibited wide variations among participants and conditions.
- ~70% of samples exceeded the WADA prohibited limit of 150 μg·ml(-1).
Conclusions:
- Hydration status does not influence urinary PSE levels after prolonged exercise.
- Urinary PSE excretion is unpredictable in athletes.
- Athletes are strongly advised to avoid medications containing PSE during competition to prevent anti-doping rule violations.
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