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Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
Published on: July 29, 2011
Strategy of Daiichi Sankyo discovery research in oncology
Kouichi Akahane1, Kazunori Hirokawa
1*Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. akahane.koichi.c8@daiichisankyo.co.jp.
Abstract:
We would like to introduce Daiichi Sankyo's approach to developing cancer targeted medicines with special reference to the drug discovery strategy, global discovery activities and external research collaboration leading to generation of innovative drugs for cancer patients. We are developing 14 clinical projects for cancer treatment and three of them have been previously approved. These are mostly targeted for growth and survival signals of cancer cells. To overcome the drug resistance mechanism derived from the heterogeneous nature of cancer, we are developing selective inhibitors in three major clusters of signal pathways which may allow future rational combinations of oncology products. In addition to the main research facility in Japan, research sites in the EU and the USA provide us with different technical expertise and diversified ideas of drug discovery. To access novel drug targets, we are facilitating research collaboration with leading academia and successful cancer research scientists. In conclusion, we intend to focus more on developing innovative personalized medicines for better treatment of cancer.
Insights
Daiichi Sankyo focuses on innovative cancer targeted medicines, developing 14 clinical projects and leveraging global research collaborations. Their strategy targets cancer cell growth and survival signals to overcome drug resistance.
Area of Science:
- Oncology
- Pharmaceutical Drug Discovery
Background:
- Daiichi Sankyo is actively developing targeted cancer therapies.
- The company has 14 clinical projects underway, with three drugs already approved.
- Current therapies primarily target cancer cell growth and survival pathways.
Purpose of the Study:
- To outline Daiichi Sankyo's comprehensive strategy for developing innovative cancer targeted medicines.
- To highlight the company's global discovery efforts and external research collaborations.
- To emphasize the focus on personalized medicine for improved cancer treatment.
Main Methods:
- Implementing a drug discovery strategy focused on targeted therapies.
- Conducting global research and development activities across multiple sites (Japan, EU, USA).
- Facilitating external research collaborations with academic institutions and scientists.
Main Results:
- Development of 14 clinical projects for cancer treatment, including three approved drugs.
- Focus on selective inhibitors targeting key cancer cell signaling pathways.
- Establishment of diverse research expertise through international collaboration.
Conclusions:
- Daiichi Sankyo is committed to advancing targeted cancer therapies.
- The company aims to overcome drug resistance through rational combination strategies.
- Future efforts will prioritize the development of innovative personalized medicines for cancer patients.
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