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Histologic study of collagen and stem cells after radiofrequency treatment for aging skin
Yusuke Yokoyama1, Hirotaka Akita, Seiji Hasegawa
1Department of Dermatology, Daido Hospital, Nagoya, Japan; Department of Dermatology, School of Medicine, Fujita Health University, Toyoake, Japan.
Background:
Monopolar radiofrequency (mRF) devices have been shown to be clinically effective for treating aging skin, but there are few histologic studies about the mechanisms.
Objective:
To histologically analyze chronologic and quantitative change in collagens after mRF treatment to determine the mechanisms of the antiaging effect.
Methods:
Five patients were enrolled in this study. Skin specimens were taken before and 1 and 3 months after treatment. Immunostaining was performed to determine change in type I and III collagen levels and stem and other cell counts in skin layers.
Results:
In all cases, both types of collagen significantly increased after irradiation in the dermis (p < .05), and their changes were noticed uniformly in all layers. No significant change was noticed in stem and other cell counts.
Conclusions:
This study histologically demonstrated that type I and III collagen increased significantly in the dermis after mRF treatment. The amount of stem cells did not affect the increase in collagens.
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