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[Basophil degranulation test in suspected mould allergy].
H Keller1, J Madjar, A Schapowal
1Univ.-Hals-Nasen-Ohrenklinik Heidelberg.
Laryngologie, Rhinologie, Otologie
|September 1, 1987
Summary
The human basophil degranulation test (HBDT) shows strong correlations with both skin and nasal tests for diagnosing mould allergies. This in-vitro method offers a valuable, broader diagnostic approach for allergic rhinitis.
Area of Science:
- Immunology
- Allergology
Context:
- Mould allergy frequently manifests with upper airway symptoms, particularly rhinitis.
- Accurate diagnosis of mould allergy is challenging using patient history alone, necessitating further diagnostic testing.
- Existing diagnostic methods like skin prick tests and nasal provocation tests can yield differing results.
Purpose:
- To investigate the correlation between the human basophil degranulation test (HBDT), intracutaneous skin tests, and nasal provocation tests in patients with suspected mould allergy.
- To evaluate the utility of HBDT as an in-vitro diagnostic tool for mould-induced allergic rhinitis.
Summary:
- The study compared HBDT, skin tests, and nasal provocation tests in 30 patients with perennial allergic rhinitis due to moulds.
- HBDT and nasal tests identified more positive reactions compared to skin tests.
- Pearson's correlation analysis indicated a stronger association between HBDT and the in-vivo tests than between the two in-vivo methods themselves.
Impact:
- HBDT demonstrates a wider sensitivity spectrum, potentially detecting non-Type I allergic reactions.
- The human basophil degranulation test is considered a valuable supplementary tool in allergy diagnostics.
- Standardization of allergenic extracts and a broader range of test slides for HBDT are recommended for wider clinical application.