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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
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Multiple trichoblastomas in a dog.

Andressa G Campos1, Bruno Cogliati, Juliana M Guerra

  • 1Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil.

Veterinary Dermatology
|January 28, 2014
PubMed
Summary
This summary is machine-generated.

This case study reports the first instance of multiple trichoblastomas in a dog. Surgical resection and chemotherapy were used to treat the canine hair follicle tumors, with no recurrence observed.

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Area of Science:

  • Veterinary oncology
  • Dermatopathology
  • Canine neoplasia

Background:

  • Hair follicle tumors, typically solitary and benign, usually have a favorable prognosis after surgical removal.
  • Trichoblastomas are a type of benign hair follicle tumor.

Observation:

  • A 2-year-old crossbred dog presented with multiple cutaneous nodules on its face.
  • These nodules, ranging from 2 to 9 cm, were located periocularly, perilabially, submandibularly, and nasally.
  • New nodules appeared within three weeks, indicating rapid tumor growth.

Findings:

  • Histopathology and immunohistochemistry confirmed the diagnosis of trichoblastoma in all resected nodules.
  • The dog underwent two surgical procedures for nodule resection.
  • Chemotherapy with doxorubicin and piroxicam was administered prior to the second surgery to manage tumor growth.

Implications:

  • This is the first documented case of multiple trichoblastomas in a canine patient.
  • While generally benign, trichoblastomas can manifest as multiple tumors requiring aggressive treatment.
  • Successful management involved surgical excision and chemotherapy, with no recurrence noted for 10 months post-surgery.