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[Serious systemic adverse events associated with allergen-specific immunotherapy in children with asthma]

Li Dai1, Ying Huang, Ying Wang

  • 1Department of Pediatrics, People's Hospital of Deyang City, Deyang, Sichuan 618000, China. huangying62@126.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|January 28, 2014
PubMed

Insights

Serious systemic adverse events from standardized dust-mite vaccines are rare in children with allergic asthma. Conventional medications effectively manage these events, showing immunotherapy

Area of Science:

  • Allergy and Immunology
  • Pediatric Pulmonology
  • Pharmacovigilance

Context:

  • Asthma affects millions of children worldwide, with dust mites being a common allergen.
  • Allergen-specific immunotherapy (ASIT) is a treatment option for allergic asthma.
  • Assessing the safety profile of ASIT in pediatric populations is crucial.

Purpose:

  • To retrospectively evaluate the incidence and characteristics of serious systemic adverse effects associated with a standardized dust-mite vaccine in children with asthma.
  • To analyze the management and outcomes of these adverse events.

Summary:

  • A review of 704 children (5-17 years) with asthma found that 17.0% experienced systemic adverse reactions to a dust-mite vaccine, with 5.4% being serious (level 3).
  • Serious events included a 20% drop in peak expiratory flow, cough, wheezing, and urticaria, primarily in younger children (5-11 years) during summer.
  • No anaphylactic shock (level 4) was recorded. Treatment with inhaled corticosteroids, beta-agonists, antihistamines, and in severe cases, dexamethasone or adrenaline, led to significant symptom relief.

Impact:

  • This study indicates a low rate of serious adverse events with standardized dust-mite immunotherapy in pediatric allergic asthma.
  • Findings support the safety of ASIT in children when properly monitored.
  • Effective management strategies exist for immunotherapy-associated adverse events, ensuring patient safety.
Abstract

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