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Developmentally regulated collagen/integrin interactions confer adhesive properties to early postnatal neural stem

Tobias Bergström1, Karin Holmqvist2, Tatsiana Tararuk1

  • 1Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, SE-75185 Uppsala Sweden.

Biochimica Et Biophysica Acta
|January 28, 2014
PubMed
Summary

Early postnatal neural stem cells adhere to collagen I via integrin β1, a property lost in adult brain stem cells. This difference highlights the dynamic extracellular matrix regulation of the developing neurogenic niche.

Keywords:
Cell adhesionIntegrin alphaIntegrin beta1Neurovascular niche

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