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Is there a correlation between coronary artery ectasia and neutrophil-lymphocyte ratio?
Ahmet Arif Yalcin1, Mustafa Topuz2, Ibrahim Faruk Akturk3
1Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery, Training and Research Hospital, Istanbul, Turkey yalcin_arif@hotmail.com.
Insights
The neutrophil-lymphocyte ratio (NLR) is associated with coronary artery ectasia (CAE). Higher NLR levels were observed in patients with CAE, suggesting its role in this condition.
Area of Science:
- Cardiology
- Hematology
- Inflammation research
Background:
- Coronary artery ectasia (CAE) is a complex vascular condition.
- The role of inflammation in CAE pathogenesis is increasingly recognized.
- Neutrophil-lymphocyte ratio (NLR) is a readily available marker of systemic inflammation.
Purpose of the Study:
- To investigate the association between NLR and CAE.
- To compare NLR levels in patients with normal coronary arteries, coronary artery disease (CAD), isolated CAE, and CAE with CAD.
Main Methods:
- Retrospective analysis of 198 patients undergoing coronary angiography.
- Patients categorized into four groups: normal, CAD, isolated CAE, and CAE with CAD.
- Comparison of NLR, neutrophil, and lymphocyte counts across groups.
Main Results:
- NLR was significantly lower in normal coronary arteries group compared to others.
- NLR was significantly higher in the CAE with CAD group.
- Positive correlations found between ectasia presence/extent and NLR.
- Isolated CAE and CAD groups showed similar NLR, neutrophil, and lymphocyte counts.
Conclusions:
- NLR is significantly associated with coronary artery ectasia.
- Elevated NLR may indicate a higher risk or severity of CAE.
- NLR could serve as a potential biomarker in the evaluation of CAE.
Abstract:
We aimed to investigate the association between the neutrophil-lymphocyte ratio (NLR) and coronary artery ectasia (CAE). The study included 198 patients who had undergone coronary angiography for suspected coronary artery disease (CAD). The patients were divided into the following 4 groups: group 1, 44 patients with normal coronary arteries; group 2, 61 patients with CAD; group 3, 40 patients with isolated CAE; and group 4, 53 patients with CAE coexisting with CAD. Neutrophil-lymphocyte ratio was significantly lower in group 1 than the other groups and significantly higher in group 4. Patients in group 1 had significantly lower neutrophil counts and significantly higher lymphocyte counts than the patients in group 4. The isolated CAE and CAD groups were similar in terms of NLR, neutrophil count, and lymphocyte count. In addition, we found significant positive correlations between presence of ectasia, number of ectatic vessels, and NLR. Our findings provide additional evidence for the role of NLR in CAE.
