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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Antigenic Liposomes for Generation of Disease-specific Antibodies
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Hydrolyzed formulas for allergy prevention.

Yvan Vandenplas1, Jatinder Bhatia, Raanan Shamir

  • 1*UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium †Division of Neonatology, Department of Pediatrics, Georgia Regents University, Augusta ‡Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel §Department of Pediatrics, IRCCS Ospedale Maggiore Policlinico, DISCCO, University of Milan, Milan, Italy ||Department of Pediatrics, Jeanne de Flandre Lille University Children's Hospital, Faculty of Medicine, University of Lille 2, Lille, France ¶Department of Translation Medical Science, Section of Pediatrics, University of Naples "Federico II," Naples, Italy #Department of Pediatrics, Medical University of Warsaw, Warsaw, Poland.

Journal of Pediatric Gastroenterology and Nutrition
|January 28, 2014
PubMed
Summary
This summary is machine-generated.

Hydrolyzed infant formulas, including extensively hydrolyzed casein and partially hydrolyzed whey, can reduce allergy risk in high-risk infants. These formulas are recommended when breastfeeding is not possible up to 4-6 months.

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Area of Science:

  • Pediatrics
  • Allergy Prevention
  • Infant Nutrition

Background:

  • Formula feeding is common when breastfeeding is not possible.
  • Infant allergies are a significant concern.
  • Hydrolyzed formulas are an alternative to standard formulas.

Purpose of the Study:

  • To provide recommendations on using hydrolyzed formulas for infants.
  • To assess the efficacy of hydrolyzed formulas in allergy prevention.

Main Methods:

  • Overview of systematic reviews.
  • Systematic review of subsequent trials.

Main Results:

  • Eight systematic reviews were identified.
  • Limited quality data from one subsequent study.
  • Extensively hydrolyzed casein and partially hydrolyzed whey formulas reduce allergy risk in high-risk infants.

Conclusions:

  • Hydrolyzed formulas are indicated for high-risk infants when breastfeeding is not feasible.
  • Documented safety and efficacy support their use up to 4-6 months.
  • Recommendations are provided for initiating formula feeding with hydrolysates.