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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

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Published on: February 19, 2021

Magnetic resonance spectroscopy findings as related to fatigue and cognitive performance in multiple sclerosis

Anna Pokryszko-Dragan¹, Joanna Bladowska², Anna Zimny²

¹Department of Neurology, Medical University of Wroclaw, Poland.

Journal of the Neurological Sciences

|January 29, 2014

Abstract

Background:

The origin of fatigue in multiple sclerosis (MS) remains unclear. Magnetic resonance spectroscopy (MRS) provides an insight into metabolic properties of the brain.

Objectives:

The aim of the study was to evaluate brain MRS measurements in MS patients, with regard to fatigue and cognition.

Methods:

The study comprised 32 MS patients and 43 controls. Fatigue was assessed using the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS) and cognition - using the Brief Repeatable Battery of Neuropsychological Tests (parts of BRBNT). MRS voxels were placed in the parietal white matter (PWM) and the posterior cingulate gyrus (PCG); N-acetyl-aspartate (NAA), choline (Cho) and myoinositol (mI) to creatine (Cr) ratios were determined. Relationships were searched between MRS measurements and fatigue as well as BRBNT results.

Results:

MS patients in comparison with controls showed decreased NAA/Cr and increased mI/Cr ratios in PCG and PWM, respectively. No significant relationships between MRS parameters and fatigue measures, BRBNT results or MS-related variables were found.

Conclusions:

The decrease of NAA and increase of mI within white and gray matters in MS patients do not show a significant relationship with cognitive performance or fatigue.

Keywords:

Axonal loss Cognition Fatigue Magnetic resonance spectroscopy Multiple sclerosis Neuroimaging

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