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Isolation of cDNAs coding for epitopes shared by microtubule-associated proteins and neurofibrillary tangle in
J P Brion1, M E Cheetham, P A Robinson
1St. George's Hospital Medical School, Department of Immunology, London, England.
FEBS Letters
|December 21, 1987
Abstract:
5 cross-hybridizing cDNA clones of sizes 2.2 (3 cDNAs), 1.3 and 0.8 kb corresponding to tau microtubule-associated protein have been isolated from a rat brain lambda gt11 expression library. Antibodies affinity-purified using the fusion protein encoded by the cDNAs were observed to label tau polypeptides on Western blots and Alzheimer's neurofibrillary tangles.