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Association between R353Q polymorphism for coagulative factor VII and severity of coronary artery disease in Iranian

Sara Cheraghi, Shokoufeh Shajiee, Mohammad Ali Boroumand1

  • 1Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. maboroumand@yahoo.com.

Cardiology Journal
|January 29, 2014
PubMed

Insights

This study found no link between factor VII R353Q polymorphism and coronary artery disease (CAD) presence or severity in the Iranian population. Further research on genetic factors in atherosclerosis is warranted.

Area of Science:

  • Cardiovascular Genetics
  • Atherosclerosis Research
  • Population Genetics

Background:

  • Coagulative factors are implicated in atherosclerosis and coronary artery disease (CAD) development.
  • The R353Q polymorphism of factor VII is a potential genetic marker.
  • Investigating genetic associations in diverse populations is crucial for understanding CAD etiology.

Purpose of the Study:

  • To investigate the association between factor VII R353Q polymorphism and the occurrence and severity of CAD.
  • To analyze the relationship in a large Iranian population sample.
  • To contribute to the understanding of genetic risk factors for CAD.

Main Methods:

  • A cohort of 919 patients with suspected CAD undergoing coronary angiography was studied.
  • CAD severity was assessed using the Gensini score and the number of diseased coronary vessels.
  • Factor VII R353Q polymorphism was genotyped using the PCR-RFLP method.

Main Results:

  • Allele frequencies for the R353Q polymorphism did not significantly differ between patients with and without CAD (p = 0.625).
  • No significant association was found between genotypes and the number of diseased vessels (p = 0.379).
  • Gensini scores showed no statistically significant differences across QQ, QR, and RR genotypes (p = 0.084).

Conclusions:

  • The R353Q polymorphism of factor VII is not associated with the presence or progression of CAD in the studied Iranian population.
  • Genetic variations in factor VII may not play a significant role in CAD development in this demographic.
  • Further studies are needed to explore other genetic and environmental factors influencing CAD.
Abstract

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