[Regulation and disorders of calcium and phosphate metabolism]
1Department of Bone and Mineral Research, Osaka Medical Center and Research Institute for Maternal and Child Health, Japan.
Abstract:
Calcium and phosphate are the constituents of biomineral, and their levels in circulation are regulated by various hormones. Disorders in calcium/phosphate metabolism are often associated with skeletal demineralization and pathological calcification. Some of the hypophosphatemic rickets/osteomalacia are caused by the increased bioactivity of FGF23, and classified into FGF23-mediated hypophosphatemic rickets/osteomalacia. In the adult patients with FGF23-mediated hypophosphatemic rickets/osteomalacia, mineralizing enthesopathy is an often observed complication. In addition, mutations of the same genes can be responsible for both rickets/osteomalacia and ectopic calcification.
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