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Updated: May 3, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs
Dincer Yilmaz1, Necdet Dogan2, Aydin Ozkan3
1Ardahan Military Hospital, Ardahan, Turkey.
Purpose:
To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects.
Methods:
Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12th postoperative week and the tibial bones were removed, histologic sections were prepared and the experimental sites were examined microscopically and stereologically.
Results:
Histologic and stereologic examination revealed more new bone formation in the defects filled with PRF mixed β-TCP than in the defects grafted with either β-TCP or PRF alone.
Conclusion:
The platelet rich fibrin and beta tricalcium phosphate combination effectively induces new bone formation.
