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Glucocorticoids in laryngology: a review
Benjamin Rafii1, Shaum Sridharan, Salvatore Taliercio
1NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, New York.
Objectives/Hypothesis:
To provide the otolaryngologist an evidence-based sound review of glucocorticoid use for laryngeal pathology.
Study Design:
Review of contemporary peer-reviewed literature as well as review articles.
Methods:
A review of the literature regarding glucocorticoids as a therapeutic intervention for the treatment of benign laryngeal pathology and laryngeal manifestations of systemic disease was performed. Review included both systemic administration as well as local injection.
Results:
Glucocorticoids, administered in the critical care setting for planned extubation, markedly reducing the risk of reintubation and remain a rudimentary pharmacologic adjunct in laryngeal manifestations of common autoimmune and inflammatory disorders. Intralesional injection has reduced the rate of surgical intervention for benign inflammatory primary laryngeal pathology.
Conclusions:
Glucocorticoids are effective in the treatment of a number of laryngeal pathologies, through both systemic and intralesional administration. However, a clear consensus for utilization of glucocorticoids in the treatment of specific laryngeal disorders has yet to be published.
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