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Alterations in antibiotic susceptibility of urinary tract infection pathogens
Ali Ghorbani1, Ali Ehsanpour2, Navid Roshanzamir1
1Department of Nephrology, Golestan Hospital, Ahvaz Jundishpur University of Medical Sciences, Ahvaz, Iran.
Background:
Urinary tract infection (UTI) is the third most common infection in human. New resisted strains of uropathogens have been developed due to different factors such as widespread use of antibiothics.
Objectives:
We conducted this study to assess the recent pattern and susceptibility of uropathogens.
Materials And Methods:
This descriptive cross-sectional study was carried on 32600 ambulatory patients' urine samples from six laboratories from 2008 to 2010 in Ahvaz, Khuzestan. Of those, 3000 positive culture were found. Data including underlying disease, pregnancy, catheterization and drug history were gathered by questionnaire. Susceptibility of pathogens to eight antimicrobial agents was determined.
Materials And Methods:
This descriptive cross-sectional study was carried on 32600 ambulatory patients' urine samples from six laboratories from 2008 to 2010 in Ahvaz, Khuzestan. Of those, 3000 positive culture were found. Data including underlying disease, pregnancy, catheterization and drug history were gathered by questionnaire. Susceptibility of pathogens to eight antimicrobial agents was determined.
Results:
Mean age of patients was 33.87 ± 3.80 years and 84.9% of them were female. The results showed that, E. coli, Kelebsiella and Enterobacter were the most common pathogens (73.5%, 13.8% and 6.6%, respectively). E. coli was susceptible to Ciprofloxacin, Amikacin, and Nitrofurantoin in 76.9%, 76.4% and 76.1% of cases, respectively. Klebsiella was more susceptible to Ciprofloxacin, Ceftizoxim and Amikacin in 81.1%, 79.9% and 87.7% of positive cultures. Enterobacter was most susceptible to Ciprofloxacin (71.7%), but completely resistant to Ampicillin unexpectedly.
Conclusions:
E. coli and other isolates were more sensitive to Gentamicin, Amikacin and Ciprofloxacin compared to the other antibiotics tested and therefore these may be the drugs of choice for the empiric treatment of community-acquired UTI in our region.
Insights
This study assessed uropathogen susceptibility in Ahvaz, finding E. coli and Klebsiella resistant to common antibiotics. Ciprofloxacin, Amikacin, and Gentamicin show promise for treating community-acquired urinary tract infections (UTIs).
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Urinary tract infections (UTIs) are a common human infection.
- Increasing antibiotic resistance in uropathogens poses a significant public health challenge.
- Emergence of resistant strains is linked to factors including widespread antibiotic use.
Purpose of the Study:
- To evaluate the current patterns of uropathogen prevalence.
- To determine the antimicrobial susceptibility profiles of common uropathogens.
- To inform empirical treatment strategies for UTIs in the Ahvaz region.
Main Methods:
- A descriptive cross-sectional study was conducted.
- 32,600 ambulatory patients' urine samples were analyzed from six laboratories (2008-2010).
- Antimicrobial susceptibility testing was performed on 3,000 positive cultures against eight agents.
Main Results:
- The most frequent uropathogens were E. coli (73.5%), Klebsiella (13.8%), and Enterobacter (6.6%).
- E. coli showed susceptibility to Ciprofloxacin (76.9%), Amikacin (76.4%), and Nitrofurantoin (76.1%).
- Klebsiella and Enterobacter exhibited significant susceptibility to Ciprofloxacin and Amikacin, with Enterobacter showing unexpected resistance to Ampicillin.
Conclusions:
- E. coli and other uropathogens demonstrated higher sensitivity to Gentamicin, Amikacin, and Ciprofloxacin.
- These antibiotics are recommended as potential drugs of choice for empirical treatment of community-acquired UTIs.
- Findings highlight the need for ongoing surveillance of antimicrobial resistance patterns.
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