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Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT
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Intracellular delivery of functionally active proteins using self-assembling pyridylthiourea-polyethylenimine

Viktoriia Postupalenko1, Annie-Paule Sibler2, Dominique Desplancq2

  • 1LCAMB UMR 7199, CNRS Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, 67401 Illkirch, France.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 31, 2014
PubMed
Summary

This study introduces a novel pyridylthiourea-modified polyethylenimine (πPEI) for efficient intracellular protein delivery. The self-assembling πPEI protects and delivers functional proteins, including antibodies, into mammalian cells for research and potential therapeutics.

Keywords:
AntibodiesDelivery vehicleIntracellular protein deliveryPolyethyleniminePolymerTransfection

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