Related Experiment Video
Updated: May 3, 2026

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
Published on: May 24, 2016
Signalling between microvascular endothelium and cardiomyocytes through neuregulin
Emily M Parodi1, Bernhard Kuhn
1Harvard Medical School, Boston Children's Hospital, 300 Longwood Avenue, Enders Building, Room 1212, Brookline, MA 02115, USA.
Abstract:
Heterocellular communication in the heart is an important mechanism for matching circulatory demands with cardiac structure and function, and neuregulins (Nrgs) play an important role in transducing this signal between the hearts' vasculature and musculature. Here, we review the current knowledge regarding Nrgs, explaining their roles in transducing signals between the heart's microvasculature and cardiomyocytes. We highlight intriguing areas being investigated for developing new, Nrg-mediated strategies to heal the heart in acquired and congenital heart diseases, and note avenues for future research.
Related Concept Videos
Paracrine Signaling
Paracrine Signaling
Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
Notch Signaling Pathway
Regulation of Angiogenesis and Blood Supply
Contact-dependent Signaling
Gap Junctions
In animal cells, gap junctions are formed...

