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Mesalazine-induced renal calculi.
Henrik Jacobsson1, Jaran Eriksen2, Per Karlén1
1Division of Medicine, Department of Clinical Sciences, Karolinska Institute, Danderyd Hospital, Stockholm, Sweden.
The American Journal of Case Reports
|January 31, 2014
Summary
Mesalazine, used for ulcerative colitis, can cause kidney stones. A 32-year-old woman experienced renal colic due to mesalazine precipitation in her urinary tract, highlighting a rare adverse effect.
Area of Science:
- Gastroenterology and Hepatology
- Clinical Pharmacology
- Nephrology
Background:
- Mesalazine (5-aminosalicylic acid) is a primary treatment for ulcerative colitis.
- While generally safe, mesalazine can cause adverse reactions including nephrotoxicity.
- Previous reports documented kidney, heart, and pancreas issues associated with mesalazine.
Purpose of the Study:
- To report a rare case of mesalazine-induced renal colic.
- To highlight an unexpected adverse drug reaction to mesalazine.
- To increase physician awareness of this potential complication.
Main Methods:
- Case report of a 32-year-old female patient with colitis.
- Clinical evaluation included CT scan of the urinary tract and cystoscopy.
- Stone analysis was performed, alongside a gynecological consultation.
Main Results:
- The patient developed recurrent renal colic after starting mesalazine.
- Biochemical analysis revealed kidney stones composed of crystallized mesalazine.
- This represents the first documented instance of mesalazine precipitating in the urinary tract.
Conclusions:
- Mesalazine can precipitate in the urinary tract, leading to renal colic.
- Physicians must be aware of this potentially severe adverse effect.
- Early recognition is crucial for managing patients on mesalazine therapy.
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