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Updated: May 3, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Obstructive sleep apnea (OSA): a complication of acute infectious mononucleosis infection in a child
1Division of Pediatric Otolaryngology, Cohen Children's Medical Center, New Hyde Park, NY, United States; Department of Otolaryngology - Head and Neck Surgery, North Shore-LIJ School of Medicine, Hempstead, NY, United States.
Insights
Acute obstructive sleep apnea (OSA) in children due to Epstein-Barr virus (EBV) infection is rare. This case highlights medical management with corticosteroids and CPAP, an alternative to surgery.
Area of Science:
- Pediatric Pulmonology
- Pediatric Infectious Diseases
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) and Epstein-Barr virus (EBV) infection are common in children.
- Acute EBV infection rarely causes acute-onset OSA.
Observation:
- A child presented with acute-onset obstructive sleep apnea during an EBV infection.
- Previous management often involved urgent adenotonsillectomy.
Findings:
- The patient's OSA was successfully managed medically.
- Treatment included systemic corticosteroids and non-invasive continuous positive airway pressure (CPAP).
Implications:
- Medical management is a viable alternative to surgery for acute OSA secondary to EBV infection in children.
- Highlights an updated, less invasive approach to a rare pediatric respiratory complication.
Abstract:
Independently, obstructive sleep apnea (OSA) and infectious mononucleosis are not uncommon in the pediatric population, but acute onset of OSA, as a respiratory complication in the setting of acute EBV infection is extremely uncommon. Previous reports of this clinical entity are sparse and from nearly two decades ago. Urgent adenotonsillectomy was commonly advocated. This complication may be managed medically with systemic corticosteroids and non-invasive continuous positive airway pressure (CPAP), and a case is presented to highlight an updated management approach to this rarely encountered clinical problem in children.
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