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Acute phase reactants and complement activation in patients with acute myocardial infarction.
T E Mollnes1, K E Tambs, Y Myreng
1Institute of Immunology and Rheumatology, National Hospital, Oslo, Norway.
Complement (Basel, Switzerland)
|January 1, 1988
Summary
Acute myocardial infarction (AMI) patients show elevated levels of C-reactive protein (CRP) and orosomucoid, but not systemic complement activation. This study found no link between CRP, complement activation, and infarct size in non-complicated AMI.
Area of Science:
- Biochemistry
- Immunology
- Cardiology
Background:
- Acute phase proteins like C-reactive protein (CRP) and complement components are often elevated in acute myocardial infarction (AMI).
- The relationship between systemic inflammation markers and complement activation in AMI requires further investigation.
Purpose of the Study:
- To quantify acute phase proteins and complement activation markers in patients with non-complicated AMI.
- To determine if elevated CRP and other acute phase reactants correlate with systemic complement activation or infarct size.
Main Methods:
- Quantified CRP, orosomucoid, alpha 1-antitrypsin, haptoglobin, C3, C4, C3 activation products, and SC5b-9 in 21 AMI patients and 22 controls.
- Samples were collected at admittance and on days 1, 2, 3, and 6 post-admittance.
Main Results:
- Peak and median concentrations of all quantified proteins were higher in the AMI group compared to controls.
- Significant differences were observed only for C-reactive protein (CRP) and orosomucoid.
- No correlation was found between CRP levels and complement activation, nor between complement activation and infarct size.
Conclusions:
- Elevated CRP and orosomucoid are present in non-complicated AMI but do not appear to be associated with systemic fluid-phase complement activation.
- Systemic complement activation, unlike local activation in infarcted myocardium, could not be demonstrated in this cohort of non-complicated AMI patients.