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Cicatricial changes in ocular pemphigus.
P Chirinos-Saldaña1, I Zuñiga-Gonzalez1, J C Hernandez-Camarena1
1Cornea and Refractive Surgery Department, Institute of Ophthalmology 'Fundación de Asistencia Privada Conde de Valenciana', Mexico City, Mexico.
Eye (London, England)
|February 1, 2014
Summary
Ocular involvement in pemphigus frequently causes severe scarring and vision loss. Early detection and management of these cicatricial changes are crucial for preserving sight in patients with pemphigus.
Area of Science:
- Ophthalmology
- Dermatology
- Immunopathology
Background:
- Pemphigus is a group of autoimmune blistering diseases.
- Ocular involvement can lead to significant visual impairment.
Purpose of the Study:
- To characterize the clinical features of ocular involvement in pemphigus patients.
- To assess the impact of ocular involvement on visual acuity.
Main Methods:
- Retrospective review of 15 pemphigus patients diagnosed via immunopathology.
- Assessment of visual acuity, ocular symptoms, and ocular surface changes.
Main Results:
- All patients exhibited conjunctival cicatricial changes.
- A significant association was found between best corrected visual acuity (BCVA) and the severity of ocular involvement.
- Ocular diseases, systemic diseases, and pemphigus-inducing drugs were common comorbidities.
Conclusions:
- Ocular involvement in pemphigus is characterized by cicatricial changes and vision loss.
- Scarring significantly correlates with reduced BCVA.
- Comorbidities may contribute to the development of ocular cicatricial changes.
