Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.2K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.2K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

3.2K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
3.2K
Destabilization of Microtubules01:45

Destabilization of Microtubules

2.9K
The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
2.9K
Microtubule Associated Proteins (MAPs)01:42

Microtubule Associated Proteins (MAPs)

4.8K
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
4.8K
Microtubule Instability02:17

Microtubule Instability

5.0K
Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated...
5.0K
Microtubule Instability02:17

Microtubule Instability

5.2K
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Latrunculin U: a potent actin-disrupter from the Red Sea marine sponge <i>Negombata magnifica</i>.

Natural product research·2025
Same author

Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents.

Bioorganic & medicinal chemistry·2024
Same author

Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site.

Bioorganic & medicinal chemistry·2023
Same author

The Microtubule Destabilizer Eribulin Synergizes with STING Agonists to Promote Antitumor Efficacy in Triple-Negative Breast Cancer Models.

Cancers·2022
Same author

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidines as Microtubule Targeting Agents.

Molecules (Basel, Switzerland)·2022
Same author

Altertoxin II, a Highly Effective and Specific Compound against Ewing Sarcoma.

Cancers·2021

Related Experiment Video

Updated: May 3, 2026

Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues
07:21

Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues

Published on: November 17, 2023

3.0K

Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.

Cristina C Rohena1, Susan L Mooberry

  • 1University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, USA. Mooberry@uthscsa.edu.

Natural Product Reports
|February 1, 2014
PubMed
Summary

Nature-derived microtubule stabilizers, like paclitaxel (Taxol), are crucial for cancer therapy. This review explores their chemistry, biology, and potential in neurodegenerative diseases.

More Related Videos

Measurement of Microtubule Dynamics by Spinning Disk Microscopy in Monopolar Mitotic Spindles
08:31

Measurement of Microtubule Dynamics by Spinning Disk Microscopy in Monopolar Mitotic Spindles

Published on: November 15, 2019

5.5K
Spatiotemporal Subcellular Manipulation of the Microtubule Cytoskeleton in the Living Preimplantation Mouse Embryo using Photostatins
08:13

Spatiotemporal Subcellular Manipulation of the Microtubule Cytoskeleton in the Living Preimplantation Mouse Embryo using Photostatins

Published on: November 30, 2021

2.0K

Related Experiment Videos

Last Updated: May 3, 2026

Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues
07:21

Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues

Published on: November 17, 2023

3.0K
Measurement of Microtubule Dynamics by Spinning Disk Microscopy in Monopolar Mitotic Spindles
08:31

Measurement of Microtubule Dynamics by Spinning Disk Microscopy in Monopolar Mitotic Spindles

Published on: November 15, 2019

5.5K
Spatiotemporal Subcellular Manipulation of the Microtubule Cytoskeleton in the Living Preimplantation Mouse Embryo using Photostatins
08:13

Spatiotemporal Subcellular Manipulation of the Microtubule Cytoskeleton in the Living Preimplantation Mouse Embryo using Photostatins

Published on: November 30, 2021

2.0K

Area of Science:

  • Pharmacology
  • Oncology
  • Cell Biology

Background:

  • Microtubule stabilizers are natural compounds with significant roles in cancer treatment.
  • Paclitaxel (Taxol) and docetaxel (Taxotere) are prominent examples of these agents.
  • Ongoing research focuses on discovering new stabilizers and formulations for improved cancer therapy.

Purpose of the Study:

  • To review recent advancements in the chemistry and biology of diverse microtubule stabilizers.
  • To explore the origins, mechanisms, and drug resistance associated with these compounds.
  • To discuss emerging applications of microtubule stabilizers in neurodegenerative diseases.

Main Methods:

  • Literature review of natural product chemistry and pharmacology.
  • Analysis of biological mechanisms, including tubulin interactions and drug resistance.
  • Synthesis of information on diverse sources and therapeutic potentials.

Main Results:

  • Identification of various natural sources for microtubule stabilizers.
  • Elucidation of distinct binding sites and modes of interaction with tubulin.
  • Understanding of mechanisms underlying drug resistance.
  • Exploration of novel therapeutic applications beyond oncology.

Conclusions:

  • Microtubule stabilizers represent a vital class of therapeutic agents derived from nature.
  • Continued research into their chemistry and biology promises further advances in cancer treatment.
  • Emerging evidence suggests a significant role for these compounds in addressing neurodegenerative disorders.