Clinical applications of oxymorphone

Area of Science:

• Pharmacology
• Medicinal Chemistry

Background:

• Oxymorphone, a semisynthetic opioid derived from thebaine, was first developed in 1914.
• It has been available as parenteral oxymorphone hydrochloride in the US since 1959 for pain management.

Purpose of the Study:

• To review pharmacological considerations, formulations, indications, and populations for oxymorphone.
• To examine interactions, side effects, and end-organ considerations.
• To highlight the significance of newer oral formulations in pain therapy.

Main Methods:

• Literature review of oxymorphone's history, pharmacology, and clinical use.
• Analysis of traditional parenteral and newer oral formulations (immediate and extended release).
• Examination of clinical data regarding efficacy, safety, and patient populations.

Main Results:

• Oxymorphone is effective for moderate-to-severe pain.
• Newer oral formulations (approved 2006) offer customizable pain management options.
• Review covers pharmacological aspects, interactions, side effects, and end-organ effects.

Conclusions:

• Oxymorphone remains a valuable agent for pain management.
• The advent of oral formulations expands therapeutic choices for healthcare providers.
• Understanding its profile is crucial for optimizing patient care.