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Biomarkers for early detection of risk in female patients with coronary artery disease: pilot study

Sunita Mahto1, S B Sharma1, S Dwivedi2

  • 1Department of Biochemistry, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-110095.

The Journal of the Association of Physicians of India
|February 4, 2014
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) helps identify unstable angina, while Pregnancy Associated Plasma Protein-A (PAPP-A) distinguishes myocardial infarction in women with coronary artery disease (CAD). These biomarkers aid in accurate diagnosis.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Women's Health

Background:

  • Coronary artery disease (CAD) presents differently in women, often leading to delayed diagnosis.
  • Biomarkers offer a potential tool for assessing CAD severity and type.
  • Distinguishing between unstable angina (UA) and myocardial infarction (MI) is critical for timely intervention.

Purpose of the Study:

  • To evaluate specific biomarkers for differentiating coronary artery disease (CAD) subtypes in women.
  • To identify reliable markers for distinguishing unstable angina (UA) from myocardial infarction (MI) and controls.
  • To explore the diagnostic utility of pro-inflammatory markers and PAPP-A in female CAD patients.

Main Methods:

  • A case-control study involving 30 controls, 30 UA cases, and 30 MI cases.
  • Analysis of blood samples for pro-inflammatory markers: high-sensitivity C-reactive protein (hs-CRP), IL-6, and ICAM-1.
  • Assessment of Pregnancy Associated Plasma Protein-A (PAPP-A) levels.
  • Application of discriminant analysis to identify differentiating markers.

Main Results:

  • High-sensitivity C-reactive protein (hs-CRP) effectively discriminated unstable angina (UA) cases from controls.
  • Pregnancy Associated Plasma Protein-A (PAPP-A) demonstrated reliability in differentiating myocardial infarction (MI) cases from both UA and control groups.
  • Specific biomarker profiles emerged for different stages of coronary artery disease in women.

Conclusions:

  • hs-CRP is a potential biomarker for identifying unstable angina in women.
  • PAPP-A serves as a reliable marker for distinguishing myocardial infarction from unstable angina and controls in women.
  • These findings underscore the importance of targeted biomarker assessment for accurate CAD diagnosis in women.

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