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Quantitative assessment of myocardial perfusion using time-density curve analysis after elective percutaneous
Michele Esposito1, Nimish N Shah, Ravikiran Korabathina
1Molecular Cardiology Research Institute, Division of Cardiology, Tufts Medical Center, 800 Washington Street, Box #80, Boston, MA 02111 USA. Nkapur@tuftsmedicalcenter.org.
Unlabelled:
The aim of this study was to assess myocardial blush (MB) using a novel software algorithm that quantifies time-density curves (TDC) after percutaneous coronary intervention (PCI).
Methods:
Thirty-two patients referred for elective PCI were enrolled. TDC curves were generated and mean maximal myocardial contrast density (Dmax) was calculated from 5 regions of interest in the PCI territory. Dmax was normalized to contrast injected in the proximal coronary artery (DI).
Results:
Mean DI significantly increased after PCI in all subjects. Dmax correlated directly with subjective grading of Thrombolysis in Myocardial Infarction (TIMI) myocardial blush (R=0.47; P<.01). In 7 subjects referred for PCI of a chronic total occlusion (CTO), mean DI remained increased after PCI. Mean DI was lower in CTO versus non-CTO subjects; however, fold-improvement was higher after PCI of CTO lesions.
Conclusion:
Quantifying MB using TDC analysis is feasible and correlates with subjective MB grading. The clinical utility of MB quantitation after PCI requires further study.
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