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Related Concept Videos

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Dementia l: Introduction

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Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

Updated: May 3, 2026

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment
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Progressive dysphasic dementia with bucco-facial apraxia: a case report.

S F Cappa1, C A De Fanti2, R De Marco2

  • 1Clinica Neurologica, Università di Brescia, Italy.

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Single-photon emission tomography (SPET) aids in diagnosing progressive neurological syndromes. This study highlights SPET

Keywords:
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Area of Science:

  • Neurology
  • Neuroimaging

Background:

  • Progressive dementia and non-fluent aphasia indicate frontal lobe involvement.
  • Neuropsychological deficits require advanced diagnostic tools.

Purpose of the Study:

  • To evaluate a patient with progressive dementia using comprehensive diagnostic methods.
  • To assess the utility of single-photon emission tomography (SPET) in diagnosing neuropsychological syndromes.

Main Methods:

  • Neuropsychological testing.
  • Magnetic resonance imaging (MRI).
  • High-resolution single-photon emission tomography (SPET).

Main Results:

  • Severe bucco-facial apraxia correlated with reduced cerebral perfusion in the left fronto-temporal cortex.
  • SPET identified localized cerebral perfusion deficits.

Conclusions:

  • SPET is a valuable alternative to positron emission tomography (PET) for diagnosing progressive neuropsychological syndromes.
  • SPET can detect coupled reductions in metabolism and blood flow characteristic of these conditions.