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Related Concept Videos

Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

27
Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
27
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
642
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

429
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
429
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

29
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
29
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

342
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
342

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Updated: May 3, 2026

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Tics.

A J Lees1

  • 1National Hospital for Neurology and Neurosurgery, Queen Square, London WC1 3BG, UK.

Behavioural Neurology
|February 4, 2014
PubMed
Summary
This summary is machine-generated.

Tics are involuntary non-verbal expressions linked to anxiety and urges. This study suggests Gilles de la Tourette syndrome involves specific brain circuit dysfunctions.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • Tics represent a form of non-verbal communication.
  • They are often associated with obsessional, aggressive urges, and anxiety.
  • The study differentiates tics from socially acceptable emotional release motor phenomena.

Purpose of the Study:

  • To compare and contrast tics with socially acceptable forms of emotional release.
  • To propose a neurobiological basis for tics in Gilles de la Tourette syndrome.

Main Methods:

  • Comparative analysis of motor phenomena.
  • Review of existing literature on tics and Gilles de la Tourette syndrome.

Main Results:

  • Tics are characterized as incontinent non-verbal communication.
  • Obsessive, aggressive urges, and anxiety are frequently comorbid with tics.
  • Socially acceptable emotional release exhibits distinct motor patterns compared to tics.

Conclusions:

  • Gilles de la Tourette syndrome is hypothesized to involve dysfunction in frontal-limbic and basal ganglia brain circuits.
  • Understanding these circuits may offer insights into tic generation and treatment.