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Behavioural effects of receptor-specific substance P agonists
Dalia Papir-Kricheli1, Joseph Frey, Ralph Laufer
1Life Sciences Institute, Hebrew University of Jerusalem, Jerusalem 91904 Israel Institute of Chemistry, Hebrew University of Jerusalem, Jerusalem 91904 Israel School of Pharmacy, Hebrew University of Jerusalem, Jerusalem 91904 Israel.
Pain
|November 1, 1987
Summary
Synthetic substance P (SP) agonists, septide and senktide, activate distinct SP receptor subtypes. This selective activation leads to different behavioral effects, differentiating their roles in neurological responses.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Substance P (SP) is a neuropeptide involved in various physiological processes.
- Three subtypes of SP receptors are known: SP-P, SP-N, and another.
- Synthetic SP agonists like septide and senktide offer tools to study receptor function.
Purpose of the Study:
- To investigate the distinct behavioral effects of selective SP receptor agonists, septide (SP-P) and senktide (SP-N).
- To determine if specific SP receptor activation underlies previously observed SP-mediated behaviors.
Main Methods:
- Intrathecal administration of selective SP receptor agonists, septide and senktide, in a model system.
- Observation and documentation of induced behavioral changes, including motor function and responses to stimuli.
Main Results:
- Septide, a selective SP-P receptor agonist, induced intense scratching and biting without motor impairment or altered pain responses.
- Senktide, a selective SP-N receptor agonist, caused transient motor flaccidity, reduced pain responses, and wet-dog shakes.
- Distinct behavioral profiles were observed for each selective agonist.
Conclusions:
- Activation of distinct SP receptor subtypes (SP-P and SP-N) mediates different behavioral outcomes.
- The diverse effects of substance P are attributable to the activation of specific SP receptor subtypes.