Symptomatic schizophrenia with moya moya disease

Area of Science:

• Neurology
• Psychiatry
• Cerebrovascular Diseases

Background:

• Moya Moya disease is a rare, progressive cerebrovascular disorder.
• It typically presents in childhood or early adulthood with ischemic or hemorrhagic strokes.
• Neurological deficits can arise from compromised blood flow to the brain.

Purpose of the Study:

• To report a case of schizophrenia-like psychosis in a young adult with a history of Moya Moya disease.
• To explore a potential causal link between Moya Moya disease and psychosis.
• To highlight the neurobiological underpinnings of psychiatric symptoms in cerebrovascular conditions.

Main Methods:

• Case report detailing clinical presentation, diagnostic workup, and follow-up.
• Review of relevant literature on Moya Moya disease and psychiatric manifestations.
• Analysis of neuroimaging findings to correlate with clinical symptoms.

Main Results:

• A young male diagnosed with Moya Moya disease in childhood presented with schizophrenia-like psychosis 12 years later.
• Neuroimaging revealed the primary cerebral lesion site, suggesting a potential link to the psychosis.
• The patient's psychiatric symptoms were consistent with a schizophrenia spectrum disorder.

Conclusions:

• Moya Moya disease may be associated with the development of psychosis.
• Cerebral lesions in Moya Moya disease could contribute to neuropsychiatric symptoms.
• Further research is warranted to elucidate the relationship between Moya Moya disease and psychosis.